PRECISION NEUROTHERAPEUTICS LAB

from invasive mapping to noninvasive biomarkers and personalized treatments

We translate high-resolution brain mapping of mental health symptoms and circuits into adaptive treatments personalized for each individual.

Our translational approach moves systematically from invasive mapping to non-invasive biomarkers to personalized treatments. We first record directly from deep brain circuits to build high-resolution neural signatures of mood and treatment response. We then develop algorithms that decode these deep signals from noninvasive brain recordings, validating them across broader patient populations and integrating additional modalities such as facial expressions and behavior. Finally, we use these noninvasive biomarkers to guide real-time, adaptive treatments that adjust to each individual's neural responses. We hope this precision-guided approach will accelerate treatment optimization and enhance therapeutic efficacy for mental health disorders.

DISCOVER

Record directly from deep brain circuits while collecting surface signals to map the neural signatures of mood and treatment response.

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TRANSLATE

Develop algorithms that decode deep brain activity from accessible surface measurements, validated across diverse patient populations.

PERSONALIZE

Deploy real-time biomarkers to guide adaptive brain stimulation treatments tailored to each individual's neural responses.

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MISSION

Our mission is to develop precision noninvasive tools for measuring and modulating human brain activity and excitability. Through personalized brain stimulation and advanced invasive and noninvasive monitoring techniques, we create safe and targeted methods that advance both fundamental neuroscience research and clinical applications for mental health.

Mental health is central to our well being, our relationships, and to society. Unfortunately, mental healthcare is often applied in a one-size-fits-all manner, cycling through multiple treatments without reference to one’s biology as a guide, leading to reduced efficacy.

To change this, through scientific and ethical rigor we seek to better understand the fundamental principles and develop new tools to quantify 1) how brain circuits interact, 2) how treatments change these circuits, and 3) how these changes map onto clinical symptoms. A deep knowledge of the relationship between brain circuits and symptoms will reduce the stigma around mental health and translate to targeted, personalized, and more effective treatments.

The goal of our laboratory is to develop an environment conducive to team-based learning in order to train the next generation of clinically-informed circuit neuroscientists. We will be recognized for questioning the status quo with rigorous scientific experiments and will make important scientific contributions in understanding how brain stimulation alters neural circuits and behavior.